“Nothing matters except making the world a better place after you’ve been here.”
David Sinclair, PhD
Everybody grows old. Everyone dies.
But is this scientific fact? Or is it merely a story based on history and our current understanding of biology?
What if we instead consider aging as a disease? This begs the question: what is the cure?
Welcome to the mind of David Sinclair, PhD, one of the world’s leading scientific authorities on longevity, aging and how to slow its effects.
A professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging, David obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995 and worked as a postdoctoral researcher at M.I.T. where, among other things, he co-discovered the cause of aging for yeast.
The co-founder of several biotechnology companies, David is also co-founder and co-chief editor of the journal Aging. His work has been featured in a variety of books, documentaries, and media, including 60 Minutes, Nightline and NOVA. He is an inventor on 35 patents, has been lauded as one of the Top 100 Australian Innovators, and made TIME magazine’s list of the 100 most influential people in the world.
In addition, David is the author of the forthcoming book, Lifespan: The Revolutionary Science of Why We Age — and Why We Don’t Have To* which hits bookstores on Sept. 10 and is currently available for pre-order here*.
This is an absolutely fascinating conversation on all things human lifespan, aging and longevity. We begin with the specific scientific mechanisms that contribute to biological degeneration. Then we dive deep into the hard science David and his peers are examining to better understand what contributes to aging and how to prevent it.
According to David, the prospect of living to 200+ is not a pipe dream, but a very possible reality. If humans could indeed double lifespan, how would this change how you live? And what does this mean for the future of humanity?
This conversation travels deep into the scientific weeds. Perfect for the geeks among us. But it’s also grounded in practical takeaways for all of us — because David’s work isn’t just about extending lifespan. It’s about learning how to live as vibrantly and energetically as possible for as long as possible.
It’s an honor and a privilege to share this brilliant man’s pioneering work and wisdom with you today. Plus he’s a lovely guy. If you enjoyed my episode with Dr. Valter Longo (RRP #367), a fellow brilliant warrior in the longevity space, then I’m fairly confident you’re going to love this one. So break out that pen and paper, because you’re going to want to take notes on this one.
I sincerely hope you enjoy the episode.
Peace + Plants,
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Thanks to this week’s sponsors
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Note: One of the best ways to support the podcast is to support the sponsors. For a complete list of all RRP sponsors and their respective vanity url’s and discount codes, visit my Resources page and click “Sponsors”.
Pre-Order Lifespan: The Revolutionary Science of Why We Age — and Why We Don’t Have To* (Available Sept. 10 2019)
Background, Context & Reference
- Connect with David: Twitter | LinkedIn | Life Biosciences
- Harvard Medical School: The Sinclair Lab
- Harvard Medical School: Rewinding The Clock
- Harvard Magazine: Anti-Aging Approaches: David Sinclair’s anti-aging science
- TIME Magazine: Is an Anti-Aging Pill on the Horizon?
- TIME Magazine: This Compound Can Reverse Aging in Mice. Will It Work in People?
- Longevity Facts: NMN and NAD Reverse Aging of Blood Vessels in New Study
- Inside Tracker: Q&A: How Harvard’s David Sinclair Unlocked His Own Fountain of Youth
- Slate: Could A Pill Slow Aging? Geneticist David Sinclair Thinks So
- Next big Future: Anti-Aging Researcher David Sinclair Takes Metformin, NMN, NAD for Longevity
- YouTube: (VIDEO) David Sinclair Slowing down Aging | My NMN Journey
- TedMed: (VIDEO) “Can a pill a day help keep aging away?” | David Sinclair, PhD
- Book: Now We Are Six (Winnie-the-Pooh)* by A.A. Milne
- Supplement: M98 Micronized Resveratrol by Revgenetics*
Notable People Discussed
- Valter Longo, PhD: Professor in Gerontology & Biological Science, Director of the USC Longevity Institute and podcast guest
- Lenny Guarente: Professor of Biology at the MIT; best known for his research on life span extension in the budding yeast Saccharomyces cerevisiae, roundworms, and mice
Cindy L. Cain: Assistant Professor, Department of Sociology at The University of Alabama, Birmingham
- Joe Rogan: host of the JRE Podcast, stand-up comedian and retired martial artist
- Leo Szilard: was a Hungarian-German-American physicist and inventor. He conceived the nuclear chain reaction in 1933, patented the idea of a nuclear reactor with Enrico Fermi in 1934, and in late 1939 wrote the letter for Albert Einstein’s signature that resulted in the Manhattan Project that built the atomic bomb
- Peter Medawar: was a Brazilian-born British biologist, whose work on graft rejection and the discovery of acquired immune tolerance was fundamental to the practice of tissue and organ transplants
Joseph Lister: known between 1883 and 1897 as Sir Joseph Lister, Bt., was a British surgeon and a pioneer of antiseptic surgery. Lister promoted the idea of sterile surgery while working at the Glasgow Royal Infirmary
- Douglas R. Seals: University of Colorado distinguished professor, integrative physiology, expert in aging and gerontology
Related Podcasts You Might Enjoy
- RRP #367: Fasting For Longevity With Valter Longo, Ph.D.
- RRP #139: How To Live To Be 100+ With Dan Buettner
- RRP #209: Rhonda Patrick, PhD On Longevity, Epigenetics & Microbiome Health
- RRP #370: How To Be Well: Frank Lipman, MD On The Keys To A Happy & Healthy Life
- RRP #410: Dr. Dean & Anne Ornish: The Power Of Lifestyle Medicine To Undo Disease & Live Better
- RRP #157: How Do You Define True Health? Plus: Ruminations On Aging, Death & The Importance Of Open Communication
*Disclosure: Books and products denoted with an asterisk are hyperlinked to an affiliate program. We are a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for us to earn fees by linking to Amazon.com and affiliated sites.
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